Chronic reflux, also known as GERD is a common medical condition. This is where acid in the stomach refluxes into the esophagus. In the late 1980’s they introduced a new class of medications called PPIs (proton pump inhibitors). They revolutionized treatment of GERD and other acid related diseases such as peptic ulcer disease. These medications are capable of drastically lowering the amount of acid in the stomach. The PPIs on the market currently include Prilosec, Nexium, Protonix, AcipHex, Prevacid, Dexilant and Zegerid. In the past 30 years, there have been 100’s of millions of prescriptions for PPIs. Since GERD is typically a chronic disease patients are frequently put on these medications long term.